Please note: This is for information only.

Refer to local guidelines for treatment recommendations

 

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• A penicillin
• Usual adult dose 1.2 g IV QDS increasing to 1.2 g 4-hourly for streptococcal endocarditis or 2.4 g QDS for meningococcal sepsis
• Dosage reduction necessary if renal impairment
• Available IV only.
• Crosses CSF only if meninges inflamed.

Main indications

• Community acquired pneumonia
• Cellulitis
• Streptococcal endocarditis
• Other serious streptococcal infections

Active against most strains of:

• Streptococci (Group A, B, C, G, viridans, pneumoniae, milleri)
• Neisseria meningitidis
• Neisseria gonorrhoea - although many strains have low level resistance
• Clostridium difficile
• Clostridium perfringens

Not active against most strains of:

• Staphylococci
• Coliforms
• Haemophilus influenzae
• Pseudomonas
• Bacteroides fragilis