Please note: This is for information only.

Refer to local guidelines for treatment recommendations

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• A lincosamide antibiotic.
• No dosage adjustment necessary in renal impairment
• Adjust dose in hepatic impairment
• Avoid co-administration with erythromycin or neuromuscular blocking agents.
• Very good bioavailability when given orally
• Good penetration into tissue and bone.
• High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly inpatients.

Main indications:

• Serious streptococcal infections (eg: cellulitis), in combination with or as an alternative to benzylpenicillin.
• Second line agent for serious soft tissue infections due to S aureus
• Alternative to metronidazole for anaerobic infections.

Active against most strains of:

• Haemolytic streptococci
• Staphylococcus aureus – including some MRSA
• Anaerobes

Not active against most strains of:

• Enterococcus
• Eschericia coli
• Coliforms
• Pseudomonas aeruginosa