Please note: This is for information only.

Refer to local guidelines for treatment recommendations.

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• Antituberculosis agent, used in combination with other antituberculosis agents (exception prophylaxis)
• Good oral bioavailability
• Excellent tissue (including brain) and CSF penetration
• Adjust dose in severe renal impairment
• Usual combination dose is 2 tablets of Rifinah – 300 once a day (if wt>50kg). (This is a combination agent with rifampicin)
• Check liver function tests prior to starting therapy. Caution in patients with pre-existing liver disease.

Main indications

• Mycobacterial disease as part of combination therapy

Active against most strains of:

• M.tuberculosis
• Varying activity against atypical mycobacteria

Not active against most strains of:

• Non-mycobacterial bacteria