Please note: This is for information only.

Refer to local guidelines for treatment recommendations

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• A nitrofuran antibiotic used orally only
• Good oral absorption (94%) but poor serum and tissue levels obtained.
• Tissue concentrations are too low for this antibiotic to be useful in systemic infections, including pyelonephritis.
• Rapidly excreted in urine where it’s antibacterial effect is employed.
• Usual adult dose 50mg qds (increased to 100mg qds in severe chronic recurrent infection)

Main Indication

• Uncomplicated urinary tract Infections
• Prophylaxis of recurrent cystitis (low dose)

Active against most strains of:

• Most urinary coliforms e.g. E.coli
• Not active against most strains of:
• Pseudomonas aeruginosa
• Proteus spp
• Enterococci