Please note: This is for information only.

Refer to local guidelines for treatment recommendations 

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Important: Generic piperacillin/tazobactam and Tazocin® have different compatibilities with other medicines. Click here for specific information.

Piperacillin

• An anti-pseudomonal penicillin.

Tazobactam

• Inhibits ß-lactamases and thus enhances and extends the spectrum of activity of piperacillin

Tazocin:

• The combination is bactericidal.
• Usual adult dose: 4.5g iv 8 hourly.
• No oral preparation.
• Renally excreted therefore dosage adjustment necessary if renal impairment.

Main indications:

• Microbiology advice – restricted agent
• Pseudomonal infections
• Aspiration Pneumonia
• Hospital Acquired Pneumonia
• Biliary Sepsis
• Diabetic Ulcer

Active against most strains of:

• Staphylococcus aureus (not MRSA)
• Haemolytic streptococci
• Enterococcus faecalis (amoxicillin-sensitive)
• Streptococcus pneumoniae
• Haemophilus influenzae
• Escheriachia coli
• Klebsiella spp
• Coliforms
• Pseudomonas aeruginosa

Not active against most strains of:

• MRSA
• Staphylococcus epidermidis
• Enterococcus faecium (amoxicillin-resistant)