Please note: This is for information only.

Refer to local guidelines for treatment recommendations

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• A diaminopyrmidine antibiotic.
• Bacteriostatic.
• Folate antagonist – long term use can cause blood disorders.
• Usual adult treatment dose: 200mg twelve hourly orally.
• Dosage adjustment necessary in renal impairment.
• Reaches high concentrations in the lungs, kidneys and cerebrospinal fluid.
• Contraindicated in pregnancy.
• No IV preparation available.

Main indications:

• First line for uncomplicated urinary tract infections
• Active against most strains of:
• Staphylococcus aureus – including MRSA
• Escherichia coli
• Klebsiella spp
• Coliforms

Not active against most strains of:

• Anaerobes
• Strep pneumoniae