Severity
(classification)

1st line oral/iv antibiotics

Anaphylactic penicillin allergy
(see explanatory notes)

A

Minor to moderate infection

Antibiotic therapy may not be required. Consider a period of observation. If treatment is indicated - see schedule B/C

Not Applicable

B/C

Moderate to severe life threatening infection

Review doses in renal impairment

AMOXICILLIN 1g iv tds
plus
METRONIDAZOLE 500mg iv tds
plus
GENTAMICIN iv (as per local protocol)

OR
If gentamicin is contra-indicated (see GHNHSFT protocol) then use:
TAZOCIN 4.5g iv tds (monotherapy)

OR
If definite history of rash allergy but no anaphylactic penicillin allergy (see explanatory notes) then use:
MEROPENEM 1g iv tds

TIGECYCLINE 100mg iv stat as loading. Then 50mg iv bd (25mg bd in severe hepatic disease) for 5 days
plus
GENTAMICIN iv (as per local protocol)

IV to Oral Switch
(explanatory notes)

CO-AMOXICLAV 625mg po tds (monotherapy)
unless lab results indicate otherwise

Duration: 5 - 7 days according to clinical response

CIPROFLOXACIN 500mg po bd
plus
METRONIDAZOLE 400mg po tds
unless lab results indicate otherwise

 Duration: 5 - 7 days according to clinical response