Severity
(classification)

1st line oral/iv antibiotics

Anaphylactic penicillin allergy
(see explanatory notes)

A/B/C

Minor to severe life threatening infection

Review doses in renal impairment

TAZOCIN 4.5g iv tds (monotherapy)

If definite history of rash allergy but no anaphylactic penicillin allergy (see explanatory notes), use:
MEROPENEM 1g iv tds

Treatment duration: 5 - 7 days according to clinical response. Then see IV to Oral Switch below (unless lab results indicate otherwise)

TIGECYCLINE 100mg iv stat as loading. Then 50mg iv bd (25mg bd in severe hepatic disease)
plus
GENTAMICIN iv (as per local protocol)

Treatment duration: 5 - 7 days according to clinical response. Then see IV to Oral Switch below (unless lab results indicate otherwise)

IV to Oral Switch
(explanatory notes)

CO-AMOXICLAV 625mg po tds
Note: Discuss need for ongoing antibiotic prophylaxis with Gastroenterologist

CIPROFLOXACIN 500mg po bd
plus
METRONIDAZOLE 400mg po tds
Note: Discuss need for ongoing antibiotic prophylaxis with Gastroenterologist