Severity(classification)

1st line oral/iv antibiotics

Anaphylactic penicillin allergy
(see explanatory notes)

A/B/C

Minor to severe life threatening infection

Review doses in renal impairment

TAZOCIN 4.5g iv tds (monotherapy)

If definite history of rash allergy but no anaphylactic penicillin allergy (see explanatory notes), use:
MEROPENEM 500mg iv tds

Treatment duration: typically up to 5 days

TIGECYCLINE 100mg iv stat as loading. Then 50mg iv bd (25mg bd in severe hepatic disease)
plus
GENTAMICIN iv (as per local protocol)